Perioperative Metformin Use in Patients Undergoing Total Joint Replacement Surgery: A Pilot Study
The goal of this pilot, randomized, single-blind, placebo-controlled trial is to evaluate the feasibility of and provide preliminary information for a multi-center randomized controlled trial that will assess the effects of metformin on blood sugar control in patients after total hip or total knee replacement surgery. The primary objective of this study is to assess the feasibility of conducting a large, randomized trial with regards to timely recruitment, study drug administration, protocol adherence, and overall retention in patients undergoing total joint arthroplasty. Secondarily, the investigators aim to obtain preliminary estimates of group-specific outcome means and variances for primary and secondary outcomes of a larger future trial.
• Male or female, age 18-99 years
• Undergoing total hip or total knee arthroplasty, including elective, primary, and revision surgeries
• Ability to take oral medication and be willing to adhere to the prescribed metformin regimen regardless of current, past, or no metformin use.
⁃ Note: Patients with or without type 2 diabetes are considered eligible. (E.g.)
• Type 2 diabetic on metformin
• Type 2 diabetic on metformin and other medication, including insulin
• Type 2 diabetic on medication but not metformin
• Pre-diabetic
• Non-diabetic